P2X3 Rabbit anti-Human, Non-human primate, Rat, Polyclonal, Invitrogen™

Beschreibung

PA1-30936 detects P2X3 from human, non-human primate, rat samples. PA1-30936 has been successfully used in immunocytochemistry, immunohistochemistry, Western blot applications. The PA1-30936 immunogen is: VEKQSTDSGAYSIG Corresponding to residues 383-397 of the carboxy-terminus of rat P2X3 Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.