p38 Polyclonal Antibody, Invitrogen™

Beschreibung

p38 Antibody, PA5-27831, from Invitrogen. Species Reactivity: Human, Mouse; Applications: Immunocytochemistry, Immunofluorescence, Western Blot.

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Host Species: Rabbit
Cross Reactivity: Human, Mouse
Isotype: IgG
Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 227 of Human p38
Formulation: 100μL purified antibody (1mg/mL) in PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Synonyms: CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, CSAID-binding protein, Csaids binding protein, MAP kinase 14, MAP kinase Mxi2, MAP kinase p38 alpha, MAX-interacting protein 2, cytokine suppressive anti-inflammatory drug binding protein, cytokine suppressive anti-inflammatory drug-binding protein, mitogen-activ
Uniprot Accession: P47811, Q16539
Entrez GeneID: 1432, 26416
Gene Symbol: MAPK14
PA5-27831 targets p38 in IF and WB applications and shows reactivity with Human and mouse samples. The PA5-27831 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 227 of Human p38.