Learn More
panMunc13 Mouse, Unlabeled, Clone: 32, BD
Mouse Monoclonal Antibody
629.00 €
Spezifikation
Antigen | panMunc13 |
---|---|
Klon | 32 |
Konzentration | 250μg/mL |
Anwendungen | Western Blot |
Klassifikation | Monoclonal |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
---|---|---|---|---|---|---|---|---|---|
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15895749
|
BD Biosciences
610999 |
150 μg |
Dieser Artikel ist im Moment nicht verfügbar oder wird nicht mehr hergestellt. Schauen Sie bitte auf unsere Produktseite nach möglichen Alternativen |
||||||
Beschreibung
Release of neurotransmitters at the synaptic junction is a primary mechanism of neuronal communication and is regulated by the synaptic vesicle (SV) cycle. Several components of the SV cycle were initially characterized in C. elegans. One of those, unc-13, is involved in normal presynaptic function. Mammalian homologues of unc-13 are Munc13-1, 13-2, and 13-3. These neuron-specific proteins lack N-terminal homology, but are highly conserved in their C-terminal regions. Here they contain a phorbal ester binding C1-domain and two C2-domains with homology to the PKC Ca2+;/phospholipid-binding domain. The most abundant isoform, Munc 13-1, is a presynaptic receptor with high affinities for phorbol ester and DAG. In response to phorbol ester, Munc13-1 associates with the plasma membrane and acts as a stimulation dependent enhancer of neurotransmitter release. In addition, Munc13-1 interacts with components of the SV cycle (syntaxin, SNAP25, synaptobrevin, Doc2) and with a brain specific isoform of β-spectrin, a protein that interacts with the actin cytoskeleton. Thus, it is thought that Munc13 proteins function in signaling pathways that regulate the neuronal exocytic machinery.
Immunofluorescence, Western Blotting
Spezifikation
panMunc13 | |
250μg/mL | |
Monoclonal | |
Mouse | |
Cell Biology | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
IgG1 | |
Affinity Purified |
32 | |
Western Blot | |
Unconjugated | |
RUO | |
Mouse, Rat | |
Rat Munc13-1 aa. 621-834 | |
Primary | |
Store undiluted at -20°C. |
For Research Use Only.