missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Phospho-IRAK1 (Thr387) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA538284
Weitere Details : Netto-Gewicht : 0.00900kg
Beschreibung
Interleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. IRAK is associated with Toll-like receptor (TLR) and IL-1R signaling pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK′s association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.Spezifikation
Phospho-IRAK1 (Thr387) | |
Polyclonal | |
Unconjugated | |
IRAK1 | |
IL-1 Receceptor Associated Kinase, Interleukin-1 receptor-associated kinase 1, mPLK, IRAK, pelle, Pelle homolog, Pelle | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
16179, 363520, 3654 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunofluorescence | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
P51617, Q62406 | |
IRAK1 | |
A synthetic phosphopeptide derived from human IRAK1 around the phosphorylation site of Thr387 (R-G-TP-L-A) | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |