Learn More
Placental Alkaline Phosphatase Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA530311
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
Recommended positive controls: NT2D1, U87-MG. Predicted reactivity: Mouse (92%), Rat (92%), Rhesus Monkey (100%), Bovine (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Placental Alkaline Phosphatase plays an important role in the regulation of specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney for this form of alkaline phosphatase have been well characterized. Placental Alkaline Phosphatase reacts with a membrane-bound isoenzyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. Placental Alkaline Phosphatase is useful in the identification of testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of Placental Alkaline Phosphatase is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. Placental Alkaline Phosphatase has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of hypophosphatasia can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.Spezifikation
Placental Alkaline Phosphatase | |
Polyclonal | |
Unconjugated | |
ALPP | |
Alkaline phosphatase placental type; Alkaline phosphatase Regan isozyme; alkaline phosphatase, placental; alkaline phosphatase, placental type; alkaline phosphomonoesterase; ALP; Alp1; ALPP; AP-TNAP; DOA1; FLJ11281; FLJ40094; FLJ61142; FLJ93059; Germ-cell alkaline phosphatase; glycerophosphatase; HOPS; MGC161443; MGC167935; nagao Isozyme; P PLAP; PALP; PLA2P; PLAA; placental alkaline phosphatase 1; placental heat-stable alkaline phosphatase; PLAP; PLAP1; PLAP-1; rCG23846-like; Regan isozyme; TNAP; TNSALP | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
250 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunoprecipitation, Western Blot | |
1 mg/mL | |
PBS with 20% glycerol and 0.01% thimerosal; pH 7 | |
P05187 | |
ALPP | |
Recombinant fragment corresponding to a region within amino acids 318 and 535 of Human PLAP | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |