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SMN Mouse, Unlabeled, Clone: 8, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 610647

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15885559

  • 689.70 € / 1 Set
Verfügbar ab: 20-12-2022
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Beschreibung

Beschreibung

SMN (survival motor neuron) was discovered as a candidate gene, located in chromosome 5q13, for the fatal autosomal Spinal muscular atrophy (SMA) disorder. The SMN gene was missing or interrupted in a significant number of patients with SMA. The SMN protein is 294 amino acids and migrates with apparent molecular weight of 40kDa. In addition to the cytoplasm, other studies localized SMN in dots of 0.1-1.0μm within the nucleus. These novel nuclear structures were named “gems” and found associated to coiled bodies. It was also found that SMN interacts with the RGG box of hnRNP U and fibrillarin. Therefore, the biochemical function of SMN may be in the regulation of mRNA metabolism.

Immunofluorescence, Immunohistochemistry, Western Blotting

Spezifikation

Spezifikation

SMN
Monoclonal
250μg/mL
Survival Motor Neuron
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Western Blot
8
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
150 μg
Cell Biology
Rat, Mouse, Human, Canine
IgG1
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.