missing translation for 'onlineSavingsMsg'
Learn More

Stat5 (pY694) Mouse anti-Human, Unlabeled, Clone: 47, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 611964

Weitere Details : Netto-Gewicht : 0.01000kg

 Weitere Artikel aus diesem Sortiment

Artikelnummer. 15886059

  • 451.44 € / 1 Set
Verfügbar ab: 02-01-2023
Sie sich ein, um den Lagerbestand zu sehen

Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!


Beschreibung

Beschreibung

The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Seven mammalian STATs have been identified: Stat 1-4, Stat5a, 5b, and Stat6. The SH3 domain of Stat5 shows extensive homology with the SH2 domains of Stat1 and Stat2. This homology leads to speculation that it may have a broader physiological role than originally anticipated and has led to its classification as a member of the Stat family. Stat5 has been further characterized and shown to be encoded by two separate genes, Stat5a and Stat5b that share over 90% identity at the amino acid level. Further insight into the exact biological role of Stat5a and Stat5b was determined with the generation of Stat5a and Stat5b deficient mice. Stat5a was shown to be involved in lactogenesis and mammary development, while Stat5b was shown to be involved in growth hormone signaling and to play a role in liver gene expression. Both Stat5a and Stat5b share similarities, both are involved in IL-2 induced peripheral T cell proliferation. Stat5 (MGF) mRNA expression is highest in mammary gland tissue. Lower levels are found in ovary, thymus, spleen, kidney, lung, muscle, and the adrenal gland. The peptide hormone, prolactin, binds to the prolactin receptor (PRLR) to initiate the lactogenic response. There are at least three forms of PRLR; however, only the long form is able to activate the 92kDa Stat5 protein by inducing phosphorylation at Tyr694. Once phosphorylated, Stat5 becomes an essential transcription factor which binds to the β-casein gene promoter. Stat5 activity is tightly regulated throughout gestation, lactation, and post-lactation. Treatment of activated Stat5 with a protein tyrosine phosphatase results in the loss of DNA binding activity. The presence of an SH2 domain within Stat5 suggests that it may directly interact with protein tyrosine kinases (PTKs) such as JAK2.

Host Species: Mouse
Clone: 47
Isotype: IgG1, κ
Species Reactivity [for Features Main]: Human
Immunogen: Phosphorylated Sheep Stat5 Peptide

Intracellular Staining, Western Blotting

Spezifikation

Spezifikation

Stat5 (pY694)
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Phosphorylated Sheep Stat5 Peptide
50 μg
Cell Biology
Human
IgG1 κ
Western Blot
47
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.