missing translation for 'onlineSavingsMsg'
Learn More

Stat6 Mouse, Unlabeled, Clone: 23/STAT6, BD

Mouse Monoclonal Antibody

320.34 € - 596.22 €

Spezifikation

Antigen Stat6
Klon 23/STAT6
Konzentration 250μg/mL
Anwendungen Western Blot
Klassifikation Monoclonal
Mehr Spezifikationen ansehen

Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15895859
Unterlagen ansehen Aktionsdetails
BD Biosciences
611290
50 μg
320.34 €
1 Set
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 02-03-2023
Sie sich ein, um den Lagerbestand zu sehen
Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!
15805869
Unterlagen ansehen Aktionsdetails
BD Biosciences
611291
150 μg
596.22 €
1 Set
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 02-03-2023
Sie sich ein, um den Lagerbestand zu sehen
Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!
Beschreibung

Beschreibung

STATs (signal transducers and activators of transcription) are critical mediators of the biologic activity of cytokines including Interleukins (IL) 2-5, IL-7, IL-15, GM-CSF, erythropoietin and growth hormone. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of STATs by tyrosine phosphorylation. Active STATs then move to the nucleus to promote transcription of cytokine-inducible genes. Seven STAT proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat6 plays an important role in signaling pathways that lead to the differentiation of T helper type 2 (Th2) cells from uncommitted CD4 T cell precursors. Moreover, IL-4, secreted by activated T lymphocytes, basophils, and mast cells, induces specific gene expression via the induction of tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641). The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta.

Host Species: Mouse
Clone: 23
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Stat6 C-terminal Recombinant Protein
Formula Weight [Chemical]: 100kDa

Immunofluorescence, Western Blotting

Spezifikation

Spezifikation

Stat6
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
23/STAT6
Western Blot
Unconjugated
RUO
Rat, Mouse, Human
Human Stat6 C-terminal Recombinant Protein
Primary
Store undiluted at -20°C.
Sicherheitsdatenblatt (SDS)
Produktzertifizierungen

For Research Use Only.