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beta-2 Microglobulin Monoclonal Antibody (YTH470.5), PE, Invitrogen™
Rat Monoclonal Antibody
Marke: Invitrogen MA517686
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
MA5-17686 targets Beta 2-microglobulin in FACS and WB applications and shows reactivity with Human samples. The MA5-17686 immunogen is rat monoclonal antibody raised against human lymphocytes.
Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.Spezifikation
beta-2 Microglobulin | |
Monoclonal | |
0.1 mg/mL | |
PBS with 4-5mg/mL BSA and 0.02% sodium azide | |
P61769 | |
B2m | |
Rat monoclonal antibody raised against human lymphocytes. | |
50 μg | |
Primary | |
Human | |
Antibody | |
IgG2b |
Flow Cytometry | |
YTH470.5 | |
PE | |
B2m | |
B2m; B2-microglobulin; b2m-W01; b2m-W03; b2m-Z01; b2m-Z02; b2m-Z03; Beta 2 microglobin; Beta 2 microglobulin; beta 2-microglobulin; beta chain of MHC class I molecules; Beta2 microglobulin; beta-2 microglobulin; beta-2 microglobulin preprotein; beta2m; beta2-m; beta-2-microglobin; beta-2-microglobulin; beta-2-microglobulin C-terminal fragment (55 AA); Beta-2-microglobulin form pI 5.3; B-F; CDABP0092; HDCMA22P; IMD43; Lactollin; Ly-m11; MHC Class I; microglobulin beta-2; Orla-B2m | |
Rat | |
Protein G | |
RUO | |
567 | |
4° C, do not freeze | |
Liquid |
Sicherheit und Handhabung
- beta-2 Microglobulin Monoclonal Antibody (YTH470.5), PE
Signalwort
- Achtung
Gefahrenkategorie
- Schwere Augenschädigung/Augenreizung Kategorie 2
Gefahrenhinweis
- H319-Verursacht schwere Augenreizung.
Sicherheitshinweis
- P264-Nach Gebrauch gründlich waschen.
- P280-Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz tragen.
- P305+P351+P338-BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
- P337+P313-Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
Ergänzende Informationen
- MIXTURE LIST-Enthält: Lithium dodecyl sulfate, Lithium chloride, BRIJ 35