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STEMCELL Technologies BIO

Product Code. 15662517
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Menge:
1 mg
5 mg
Unit Size:
1 Milligramm
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Product Code. 15662517

Brand: STEMCELL Technologies 72032

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Description

WNT pathway activator; Inhibits GSK3

  • BIO is an indirubin compound that is cell-permeable and is a selective and potent reversible inhibitor of GSK3α and GSK3β (IC50 = 5 nM) and functions as a WNT activator
  • Enhances reprogramming of mouse fibroblasts, neural stem cells, and thymocytes to induced pluripotent stem (iPS) cells (Lluis et al.)
  • Maintains self-renewal of mouse embryonic stem (ES) cells in the absence of LIF (Sato et al.)
  • Maintains self-renewal of human ES cells in unconditioned medium through a SMAD 2/3 dependent mechanism (James et al.), Sato et al.)
  • Induces proliferation of neonatal and adult rat cardiomyocytes (Tseng et al.)
  • Promotes differentiation of cardiomyocytes from human ES and iPS cells (Lian et al.)

Specifications

CAS 667463-62-9
Synonym GSK 3 IX; MLS 2052; 6-Bromoindirubin-3'-oxime
Menge 1 mg
Summenformel C16H10BrN3O2
Reinheit ≥ 98%
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