missing translation for 'onlineSavingsMsg'
Learn More

ACROBiosystems Biotinylated Cynomolgus / Rhesus macaque CTLA-4 Protein, Avitag™,His Tag

Biotinylated Protein

Marke:  ACROBiosystems CT4-C82E5-200UG

Weitere Details : Netto-Gewicht : 0.00001kg

 Weitere Artikel aus diesem Sortiment

Artikelnummer. 15896507

  • 1733.51 € / 200 Mikrogramm
Verfügbar ab: 12-01-2023
Sie sich ein, um den Lagerbestand zu sehen

Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!


Beschreibung

Beschreibung

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4, an inhibitory receptor for B7 molecules. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 15.9 kDa. The protein migrates as 20-26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

XP_005574071.1
15.9 kDa
200 µg
Ala 37 - Ser 160
CTLA4,CD152
Precision Avi
PBS, pH7.4
HEK293
Cynomolgus / Rhesus macaque
Powder
>95% as determined by SDS-PAGE
Biotinylated Cynomolgus / Rhesus macaque CTLA-4, Avitag,His Tag (CT4-C82E5) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Ser 160 (Accession # G7PL88-1). In the region Ala 37 - Ser 160, the AA sequence of Cynomolgus and Rhesus macaque CTLA-4 are homologus.
-20°C
CTLA-4
His Tag and Avi Tag
Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote