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ACROBiosystems Biotinylated Human ErbB3 / Her3 Protein, His Tag, ultra sensitivity (primary amine labeling)

Marke:  ACROBiosystems ER3-H8223-200UG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15826687

  • 1261.00 € / 200 Mikrogramm

Voraussichtliches Versanddatum: 15-11-2021

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Beschreibung

Beschreibung

ErbB3, also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 69.5 kDa. The protein migrates as 85-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_001973.2
HEK293
Human
69.5 kDa
200 µg
Ser 20 - Thr 643
ERBB3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3
UltraLys
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
Powder
>95% as determined by reduced SDS-PAGE
MABSol™ Biotinylated Human ErbB3, His Tag, primary amine labeling (ER3-H8223) is expressed from human HEK293 cells. It contains AA Ser 20 - Thr 643 (Accession # NP_001973.2). It is the biotinylated form of Human ErbB3, His Tag (ER3-H5223).
-20°C
ErbB3
His Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate