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ACROBiosystems Biotinylated Human FOLR1 Protein, His, Avitag™

Biotinylated Protein

Marke:  ACROBiosystems FO1-H82E2-200UG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15896777

  • 1733.51 € / 200 Mikrogramm
Verfügbar ab: 05-01-2023
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Beschreibung

Beschreibung

Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 28.3 kDa. The protein migrates as 38-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_057937.1
28.3 kDa
200 µg
Arg 25 - Met 233
FOLR-1,FBP,FOLR
Precision Avi
PBS, pH7.4
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Biotinylated Human FOLR1, His,Avitag (FO1-H82E2) is expressed from human 293 cells (HEK293). It contains AA Arg 25 - Met 233 (Accession # P15328-1).
-20°C
FOLR1
His Tag and Avi Tag
Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote