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ACROBiosystems Biotinylated Human Growth Hormone R (GHR) Protein, His Tag, ultra sensitivity (primary amine labeling)
Marke: ACROBiosystems GHR-H8222-50UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.6 kDa. The protein migrates as 40-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
NP_000154.1 | |
50 μg | |
Ala 27 - Tyr 264 | |
GHR,GHBP,GH receptor | |
UltraLys | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by reduced SDS-PAGE |
29.6 kDa | |
MABSol™ Biotinylated Human GHR, His Tag, ultra sensitivity (primary amine labeling) (GHR-H8222) is expressed from human HEK293 cells. It contains AA Ala 27 - Tyr 264 (Accession # P10912-1). It is the biotinylated form of Human Growth Hormone R (GHR) Protein (GHR-H5222). | |
-20°C | |
Growth Hormone R | |
Human | |
PBS, pH7.4 | |
HEK293 | |
MABSol™ Biotin Labeled Proteins |