missing translation for 'onlineSavingsMsg'
Learn More

ACROBiosystems Biotinylated Human SOST / Sclerostin Protein, His Tag, ultra sensitivity (primary amine labeling)

Marke:  ACROBiosystems SOT-H8245-25UG

Weitere Details : Netto-Gewicht : 0.00001kg

 Weitere Artikel aus diesem Sortiment

Artikelnummer. 15897717

  • 330.73 € / 25 Mikrogramm
Verfügbar ab: 02-01-2023
Sie sich ein, um den Lagerbestand zu sehen

Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!


Beschreibung

Beschreibung

Sclerostin (SOST) also known as Sclerosteosis, VBCH, is a secreted glycoprotein with a signal peptide for secretion and a C-terminal cysteine knot-like (CTCK) domain and belongs to the Cerberus/DAN family of bone morphogenetic protein (BMP) antagonists. Sclerostin is produced by the osteocyte and has anti-anabolic effects on bone formation. More recently Sclerostin has been identified as binding to LRP5/6 receptors and inhibiting the Wnt signalling pathway. Wnt pathway inhibition under these circumstances is antagonistic to bone formation (meaning Sclerostin antagonizes bone formation). It has been shown that SOST binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. Sclerostin production by osteocytes is inhibited by parathyroid hormone, mechanical loading and cytokines including oncostatin M, cardiotrophin-1 and leukemia inhibitory factor. Sclerostin production is increased by calcitonin. Thus, osteoblast activity is self regulated by a negative feedback system. Mutations of Sclerostin is associated with the syndrome Sclerosteosis, and reduced sclerostin expression results in a milder form of the disorder called van Buchem disease.

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 22.3 kDa. The protein migrates as 25-35 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Spezifikation

Spezifikation

AAI01087.1
22.3 kDa
25 µg
Gln 24 - Tyr 213
SOST,VBCH
UltraLys
PBS, pH7.4
HEK293
Human
Powder
>95% as determined by reduced SDS-PAGE
MABSol™ Biotinylated Human SOST, His Tag, primary amine labeling (SOT-H8245) is expressed from human HEK293 cells. It contains AA Gln 24 - Tyr 213 (Accession # AAI01087.1). It is the biotinylated form of Human SOST, His Tag (HST-H5245).
-20°C
SOST
His Tag
Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote