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ACROBiosystems Biotinylated Mouse FOLR1 Protein, His, Avitag™
Biotinylated Protein
Marke: ACROBiosystems FO1-M82E9-25UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 26.9 kDa. The protein migrates as 32-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
NP_032060.2 | |
25 μg | |
Thr 25 - Ser 232 | |
FOLR-1,FBP,FOLR | |
Precision Avi | |
His Tag and Avi Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |
26.9 kDa | |
Biotinylated Mouse FOLR1, His,Avitag (FO1-M82E9) is expressed from human 293 cells (HEK293). It contains AA Thr 25 - Ser 232 (Accession # P35846-1). | |
-20°C | |
FOLR1 | |
Mouse | |
PBS, pH7.4 | |
HEK293 | |
MABSol™ Biotin Labeled Proteins |