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Catenin alpha-1 Polyclonal Antibody, Invitrogen™
Goat Polyclonal Antibody
Marke: Invitrogen PA518512
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
This antibody is predicted to react with canine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.Spezifikation
Catenin alpha-1 | |
Polyclonal | |
Unconjugated | |
CTNNA1 | |
[a]E-catenin; 102 kDa cadherin-associated protein; 2010010M04Rik; AA517462; AI988031; alpha E catenin; alpha E-catenin; alpha(E)-catenin; alpha-E-catenin; cadherin associated protein; Cadherin-associated protein; CAP102; catenin (cadherin associated protein), alpha 1; catenin (cadherin-associated protein), alpha; catenin (cadherin-associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha 1; catenin alpha 1 S homeolog; catenin alpha-1; catenin, alpha 1; Catna1; cell-adhesion protein alphaE catenin; ctnna; ctnna1; ctnna1.S; MDPT2; Renal carcinoma antigen NY-REN-13; XELAEV_18020018mg | |
Goat | |
Ammonium sulfate precipitation | |
RUO | |
1495 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.5 mg/mL | |
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
P35221 | |
CTNNA1 | |
Synthetic peptide sequence (KREKQDETQTKIK) corresponding to the internal amino acids of CTNNA1 | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |