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CD253 Mouse anti-Human, PE, Clone: RIK-2, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 550516
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
The RIK-2 monoclonal antibody specifically binds to CD253 which is also known as TRAIL (TNF-Related Apoptosis-Inducing Ligand) and Apo2 ligand (APO-2L). CD253 is a member of the Tumor Necrosis Factor Superfamily and is encoded by the TNFSF10 gene. CD253 is a type II membrane protein that may be expressed as a full-length, cell surface associated protein as well as in a soluble form. Both surface and soluble forms of TRAIL rapidly induce apoptosis by a wide range of cell lines but not by normal cells. TRAIL is expressed by activated T cells, NK cells, dendritic cells, monocytes and by a variety of non-lymphoid cells. TRAIL can bind to and exert apoptosis through DR4 (TRAIL-R1) and DR5 (TRAIL-R2) receptors. It can also bind to decoy receptors, including DcR1/TRID/TRAIL-R3 and DcR2/TRUNDD/TRAIL-R4, and possibly OPG/TNFRSF11B, which may serve to regulate TRAIL activity. TRAIL has been shown to be involved in T cell-mediated cytotoxicity, however its mechanism of action remains to be fully elucidated. The RIK-2 clone was selected based on its ability to block TRAIL-mediated cytotoxic activity.
Spezifikation
CD253 | |
Monoclonal | |
0.2mg/mL | |
TNFSF10; TRAIL; APO-2L; TL2 | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
Flow Cytometry | |
RIK-2 | |
PE | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
Human TRAIL | |
0.1 mg | |
Immunology | |
Human | |
IgG1 |
For Research Use Only.