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CD27 Hamster anti-Mouse, PE, Clone: LG.3A10, BD
Hamster Monoclonal Antibody
151.00 € - 365.00 €
Spezifikation
Antigen | CD27 |
---|---|
Klon | LG.3A10 |
Konzentration | 0.2mg/mL |
Anwendungen | Flow Cytometry |
Klassifikation | Monoclonal |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
---|---|---|---|---|---|---|---|---|---|
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15801339
|
BD Biosciences
561785 |
25 μg |
151.00 €
1 Stück |
Verfügbar ab: 24-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
15839618
|
BD Biosciences
558754 |
0.1 mg |
365.00 €
1 Stück |
Verfügbar ab: 24-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
Beschreibung
The LG.3A10 monoclonal antibody specifically binds to CD27, a lymphocyte-restricted member of the Tumor Necrosis Factor Receptor family which binds to CD70. The CD27 molecule is a 45-kDa transmembrane glycoprotein which is constitutively expressed by lymphocytes of the T lineage: virtually all thymocytes and over 90% of peripheral T cells bearing both αβ and γδ T-cell receptors. CD27 cooperates with the pre-TCR in mediating thymocyte differentiation and expansion. In addition, one to ten percent of mature peripheral B cells express CD27, and CD27’s role in the differentiation of human plasma cells has been studied. Mouse NK cells, freshly isolated and IL-2-activated, also express CD27. In the bone marrow, CD27 is found on a progenitor population which provides short-term hematopoietic reconstitution. Cells of the myeloid lineage do not express CD27. Cross-linked LG.3A10 mAb has been reported to amplify the proliferative response of purified T lymphocytes to suboptimal mitogenic stimulation1 and to enhance NK-cell proliferation and IFN-γ production. In contrast, non-cross-linked LG.3A10 mAb inhibits CD3-induced pre-T cell development by interfering with the receptor-ligand interaction. This hamster mAb to a mouse leukocyte antigen has been observed to cross-react with a similar population of rat leukocytes.
Spezifikation
CD27 | |
0.2mg/mL | |
Monoclonal | |
Hamster | |
Mouse | |
Armenian hamster fibroblast line ARHO12 transfected with mouse Cd27 cDNA | |
Primary | |
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
LG.3A10 | |
Flow Cytometry | |
PE | |
RUO | |
Aqueous buffered solution containing ≤0.09% sodium azide. | |
IgG1 κ | |
Affinity Purified |
For Research Use Only.