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CD326 (EpCAM) Mouse anti-Human, Super Bright 436, Clone: 1B7, eBioscience

Mouse Monoclonal Antibody

Marke:  Affymetrix eBioscience 62-9326-42

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 16321324

  • 301.00 € / 100 Tests

Voraussichtliches Versanddatum: 09-11-2021

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Beschreibung

Beschreibung

Description: EpCAM (Epithelial cell adhesion molecule, CD326, KSA, TROP1) is a 40 kD cell-surface adhesion molecule participating in homophilic, calcium-independent cell-cell interactions. EpCAM is a type-I transmembrane protein, and is expressed primarily on the basolateral surface of most epithelia. Although normal epithelia express low levels of EpCAM, increased expression has been correlated with increased proliferation and progression to a mesenchymal phenotype. EpCAM has also been used as a diagnostic marker on circulating metastatic carcinoma cells, while cancer cells of non-epithelial origin do not express EpCAM. Applications Reported: This 1B7 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 1B7 antibody has been pre-diluted and tested by flow cytometric analysis of A549 cells. This may be used at 5 μL (0.5 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Super Bright 436 can be excited with the violet laser line (405 nm) and emits at 436 nm. We recommend using a 450/50 bandpass filter, or equivalent. Please make sure that your instrument is capable of detecting this fluorochrome. When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer (Product No.

SB-4401) to minimize any non-specific polymer interactions. Please refer to the datasheet for Super Bright Staining Buffer for more information. Excitation: 405 nm; Emission: 436 nm; Laser: Violet Laser Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company. Ep-CAM is a ∽40 kD glycoprotein, which functions as an epithelial cell adhesion molecule. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions has a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. Ep-CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is expressed in the majority of human carcinomas and is a marker for tumors of epithelial lineage.
Spezifikation

Spezifikation

CD326 (EpCAM)
Monoclonal
5 μl/Test
PBS with BSA and 0.09% sodium azide; pH 7.2
P16422
EPCAM
IgG1, kappa
100 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
4072
Flow Cytometry
1B7
Super Bright 436
EPCAM
Liquid
Mouse
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate