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CD366 (TIM3) Monoclonal Antibody (8B.2C12), APC-eFluor™ 780, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
339.00 €
Spezifikation
Antigen | CD366 (TIM3) |
---|---|
Klon | 8B.2C12 |
Konzentration | 0.2 mg/mL |
Anwendungen | Flow Cytometry |
Klassifikation | Monoclonal |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
---|---|---|---|---|---|---|---|---|---|
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
16320904
|
Affymetrix eBioscience
47-5871-82 |
100μg |
339.00 €
100 Mikrogramm |
Verfügbar ab: 04-06-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
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Beschreibung
The 8B.2C12 monoclonal antibody reacts with mouse CD366 (TIM3), a Th1-specific cell surface protein. CD366 is a type I transmembrane protein and contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.Spezifikation
CD366 (TIM3) | |
0.2 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
Q8VIM0 | |
Havcr2 | |
Primary | |
Antibody |
8B.2C12 | |
Flow Cytometry | |
APC-eFluor 780 | |
Rat | |
Mouse | |
171285 | |
IgG1 κ | |
4° C, store in dark, DO NOT FREEZE! | |
Havcr2 |