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CD5 Monoclonal Antibody (UCHT2), Super Bright™ 702, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
152.00 € - 341.00 €
Spezifikation
Antigen | CD5 |
---|---|
Klon | UCHT2 |
Konzentration | 5 μL/Test |
Anwendungen | Flow Cytometry |
Klassifikation | Monoclonal |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
---|---|---|---|---|---|---|---|---|---|
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15913704
|
Affymetrix eBioscience
67-0059-42 |
100 Tests |
341.00 €
100 Stück |
Verfügbar ab: 03-06-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
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15903704
|
Affymetrix eBioscience
67-0059-41 |
25 Tests |
Dieser Artikel ist im Moment nicht verfügbar oder wird nicht mehr hergestellt. Schauen Sie bitte auf unsere Produktseite nach möglichen Alternativen |
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Beschreibung
Description: The eBio124-1D1 monoclonal antibody reacts with human CD7, also known as gp40 and Leu9. CD7, a 40 kD receptor, is a member of the immunoglobulin gene superfamily. The N-terminal amino acid sequence (aa1-107) is highly homologous to Ig kappa light chain sequence; while the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T lymphocytes, and T cell leukemias. It is also found on natural killer cells, a small suppopulation of normal B cells and on maligant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity, as measured by calcium flux, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. A clonogenic subpopulation of human CD34(+) CD38(-) cord blood cells that express CD45RA and HLA-DR and high levels of the CD7 has been reported. These cells possess the capacity for lymphopoiesis. They can generate B-cells, natural killer cells, and dendritic cells but do not possess the capacity to develop into myeloid cells or erythroid cells. The CD7(+) phenotype distinguishes primitive human lymphoid progenitors from pluripotent stem cells.
CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.Spezifikation
CD5 | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
P06127 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
UCHT2 | |
Flow Cytometry | |
Super Bright 702 | |
Mouse | |
Human | |
921 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! |