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CREST Rabbit anti-Human, CoraLite 488, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech CL488-12439-100UL

Weitere Details : Netto-Gewicht : 0.00010kg

Artikelnummer. 17204676

  • 367.00 € / 100 Mikroliter
Verfügbar ab: 24-06-2024
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Beschreibung

Beschreibung

CREST, also named as SS18-like 1(SS18L1) is a transcriptional activator that is required for calcium-dependent dendritic growth and branching in cortical neurons. It's also a nuclear protein interacts with CREB-binding protein and expressed in the developing brain. It helps regulate neuronal morphogenesis in calcuim-dependent manner. The N-terminal domain of SS18L1 is required for suppressing transactivation in the basal state, while the C-terminal domain is required for calcium-induced transactivation. It's part of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. This complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. The calculated molecular weight of CREST is about 43 kDa, but the modified of CREST protein is 55 kDa (PMID: 25888396). CREST exists some isoforms with calulated MV 43, 40, 33 and 29 kDa.

Spezifikation

Spezifikation

CREST
Polyclonal
CoraLite 488
100 μL
26039
Liquid
Immunofluorescence
1000 μg/mL
Rabbit
Primary
Human
IgG
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote