EphB1 Monoclonal Antibody (5F10A4), Invitrogen™

Beschreibung

MA5-15385 targets EhpB1 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples. The MA5-15385 immunogen is purified recombinant fragment of EphB1 (aa19-133) expressed in E. Coli. <br>. MA5-15385 detects EhpB1 which has a predicted molecular weight of approximately 110kDa.

EPHB1 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. EphB1 and other ephB family members are type 1 membrane spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine rich subdomains in the ecto domain, and the single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. ephB family proteins bind ephrins of the B class, ligands that are also transmembrane spanning proteins capable of transmitting signals. ephB1 is expressed predominantly in developing neural structures in embryos, and in vascular epithelium of kidney, and other tissues. Upon binding to alternatively oligomerized ephrin B1, ephB1 signals regulation of cell attachment and cellcell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.