H3K36me2 Monoclonal Antibody (T.571.7), ChIP-Verified, Invitrogen™

Beschreibung

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with di-methylated histone H3 Lys4, Lys9, Lys27, Lys79 or methylated histone H4 Lys20. Click <a href="e;https://assets.thermofisher.com/TFS-Assets/LSG/certificate/Certificates-of-Analysis/MA514867_H3K36me2.PDF"e;>here</a> for Master Lot linking information.

Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.