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ACROBiosystems Human CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin

low endotoxin

Brand:  ACROBiosystems CT4-H52A4-1MG

Additional Details : Netto-Gewicht : 0.00001kg

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Product Code. 15896517

  • 2258.12 € / 1 Milligramm
Verfügbar ab: 02-01-2023
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Description

Description

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation and 100 kDa under non-reducing (NR) condition.
Specifications

Specifications

NP_005205.2
40.6 kDa
1 mg
Ala 37 - Phe 162
CTLA4,CD152
Unconjugated
50 mM Tris, 100 mM Glycine, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human CTLA-4, mouse IgG2a Fc tag, low endotoxin (CT4-H52A4) is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162 (Accession # NP_005205.2).
-20°C
CTLA-4
Mouse IgG Fc Tag
Less than 0.1 EU / µg by the LAL method.
Immune Checkpoint Proteins
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