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ACROBiosystems Human CXCR4 / CD184 Protein, Fc Tag

Marke:  ACROBiosystems CX4-H5269-1MG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15896547

  • 3010.84 € / 1 Milligramm
Verfügbar ab: 05-01-2023
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Beschreibung

Beschreibung

C-X-C chemokine receptor type 4 is also known as fusin or CD184 (cluster of differentiation 184), CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R or WHIM. CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. Typically, these viruses are found late in infection. It is unclear as to whether the emergence of CXCR4 using HIV is a consequence or a cause of immunodeficiency.CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst, a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation. SDF-1 and CXCR4 were believed to be a relatively "e;monogamous"e; ligand-receptor pair (other chemokines tend to use several different chemokine receptors in a fairly "e;promiscuous"e; manner). Recent evidence demonstrates ubiquitin is also a natural ligand of CXCR4. Chronic exposure to THC increased T lymphocyte CXCR4 expression on both CD4+ and CD8+ T lymphocytes. Drugs that block the CXCR4 receptor appear to be capable of "e;mobilizing"e; hematopoietic stem cells into the bloodstream as peripheral blood stem cells.
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 32.3 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

AAH20968.1
32.3 kDa
1 mg
Met 1 - Ser 46
CXCR4,CD184,Fusin,D2S201E,FB22,HM89,HSY3RR,LAP3,LCR1,LESTR,NPY3R,NPYR,NPYRL,NPYY3R,WHIM
Unconjugated
50 mM Tris, 100 mM Glycine, pH7.5
HEK293
Human
Powder
>90% as determined by SDS-PAGE
Human CXCR4, Fc Tag (C x 4-H5269) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ser 46 (Accession # AAH20968.1).
-20°C
CXCR4
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
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