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ACROBiosystems Human Growth Hormone R (GHR) Protein, His Tag

Marke:  ACROBiosystems GHR-H5222-1MG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15896827

  • 2486.22 € / 1 Milligramm
Verfügbar ab: 23-12-2022
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Beschreibung

Beschreibung

Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.6 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_000154.1
29.6 kDa
1 mg
Ala 27 - Tyr 264
GHR,GHBP,GH receptor
Unconjugated
PBS, pH7.4
HEK293
Human
Powder
>90% as determined by SDS-PAGE
Human GHR, His Tag (GHR-H5222) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Tyr 264 (Accession # P10912-1).
-20°C
Growth Hormone R
His Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
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