missing translation for 'onlineSavingsMsg'
Learn More

ACROBiosystems Human IGF-II Protein, Fc Tag

Marke:  ACROBiosystems IG2-H4260-1MG

Weitere Details : Netto-Gewicht : 0.00001kg

 Weitere Artikel aus diesem Sortiment

Artikelnummer. 15896987

  • 1608.06 € / 1 Milligramm
Verfügbar ab: 02-01-2023
Sie sich ein, um den Lagerbestand zu sehen

Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!


Beschreibung

Beschreibung

Insulin-like growth factor 2 (IGF-2) is also known as Somatomedin-A, IGF-II, PP9974, and is one of three protein hormones that share structural similarity to insulin. IGF-2 exerts its effects by binding to the IGF-1 receptor. IGF2 may also bind to the IGF-2 receptor (also called the cation-independent mannose 6-phosphate receptor), which acts as a signalling antagonist; that is, to prevent IGF2 responses. The major role of IGF2 is as a growth promoting hormone during gestation. In the process of Folliculogenesis, IGF2 is created by Theca cells to act in an autocrine manner on the theca cells themselves, and in a paracrine manner on Granulosa cells in the ovary. IGF2 promotes granulosa cell proliferation during the follicular phase of the menstrual cycle, acting alongside Follicle Stimulating Hormone (FSH). After ovulation has occurred, IGF-2 promotes progesterone secretion during the luteal phase of the menstrual cycle together with Luteinizing Hormone (LH). Thus, IGF2 acts as a Co-hormone together with both FSH and LH. IGF-2 may play a key role in memory and could potentially be used to treat Alzheimer's Disease. It is sometimes produced in excess in islet cell tumours, causing hypoglycemia. Doege-Potter syndrome is a paraneoplastic syndrome in which hypoglycemia is associated with the presence of one or more non-islet fibrous tumors in the pleural cavity. has been shown to interact with IGFBP3 and Transferrin.

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 34.4 kDa. The protein migrates as 36 kDa under reducing (R) condition (SDS-PAGE).
Spezifikation

Spezifikation

P01344-1
34.4 kDa
1 mg
Ala 25 - Glu 91
IGF2,C11orf43,FLJ22066,FLJ44734,IGF-II,PP9974
Unconjugated
50 mM Tris, 100 mM Glycine, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human IGF-II, Fc Tag (IG2-H4260) is expressed from human 293 cells (HEK293). It contains AA Ala 25 - Glu 91 (Accession # P01344-1).
-20°C
IGF-II
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Cytokines and Growth Factors
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote