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ACROBiosystems Human IL-17 RA / CD217 Protein, Fc Tag
MALS verified
Marke: ACROBiosystems ILA-H5257-1MG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested . IL 17RA associates with IL 17RC to form a signaling receptor complex for IL 17 and IL 17F . Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.1 kDa. The protein migrates as 71-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
NP_055154.3 | |
1 mg | |
Leu 33 - Trp 320 | |
CD217,CDw217,IL-17 RA,IL17R,CANDF5,hIL-17 R | |
Unconjugated | |
Fc Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |
60.1 kDa | |
Human IL-17 RA, Fc Tag (MALS verified) (ILA-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (Accession # Q96F46-1). | |
-20°C | |
IL-17 RA | |
Human | |
Tris with Glycine, Arginine and NaCl, pH7.5 | |
HEK293 | |
Bio-Markers and CD Antigens |