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STEMCELL Technologies Human Recombinant IL-2 (CHO-expressed)

Interleukin 2

Marke:  STEMCELL Technologies 78036.1

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15881468

  • 122.36 € / 10 Mikrogramm
Verfügbar ab: 16-12-2022
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Beschreibung

Beschreibung

  • Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor
  • It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132
  • Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma et al.) The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts
  • IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells
  • IL-2 also controls inflammation by inhibiting Th17 differentiation
  • Human Recombinant IL-2 has a serine substitute for cysteine at position 126
Spezifikation

Spezifikation

Aldesleukin, Interleukin-2, T cell growth factor, TCGF
≥95%
10 μg
Hematopoietic Stem and Progenitor Cells; NK Cells; T Cells; T Cells, CD4+; T Cells, CD8+
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote