Learn More
ACROBiosystems Human TNFSF11 / RANKL / CD254 Protein, Fc Tag
423.38 € - 3278.17 €
Spezifikation
Zugriffsnummer | AAC51762.1 |
---|---|
Molekulargewicht | 46.9 kDa |
Quelle | Human TNFSF11, Fc Tag (RAL-H5265) is expressed from human 293 cells (HEK293). It contains AA Gly 64 - Asp 245 (Accession # AAC51762.1). |
Immunogen | Gly 64 - Asp 245 |
Lagerungsbedingungen | -20°C |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
---|---|---|---|---|---|---|---|---|---|
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
16418009
|
ACROBiosystems
RAL-H5265-1MG |
1 mg |
3278.17 €
1 Milligramm |
Verfügbar ab: 24-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
16428009
|
ACROBiosystems
RAL-H5265-50UG |
50 μg |
423.38 €
50 Mikrogramm |
Verfügbar ab: 24-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
Beschreibung
Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 46.9 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
AAC51762.1 | |
Human TNFSF11, Fc Tag (RAL-H5265) is expressed from human 293 cells (HEK293). It contains AA Gly 64 - Asp 245 (Accession # AAC51762.1). | |
-20°C | |
TNFSF11 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Bio-Markers and CD Antigens |
46.9 kDa | |
Gly 64 - Asp 245 | |
RANKL,CD254,TRANCE,OPGL,ODF | |
Unconjugated | |
Fc Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE |