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IA-2/PTPRN Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 10584-1-AP-150UL

Weitere Details : Netto-Gewicht : 0.00010kg

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Artikelnummer. 16887053

  • 329.85 € / 150 Mikroliter

Voraussichtliches Versanddatum: 23-06-2021

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Beschreibung

Beschreibung

IA-2 (insulinoma-associated protein 2, ICA512, PTPRN) is a member of the transmembrane protein tyrosine phosphatase (PTP) family located in secretory granules of neuroendocrine cells. The IA-2 protein is 979 amino acids in length and consists of a luminal domain, transmembrane domain, and cytoplasmic domain. Although a member of the PTP family, IA-2 lacks phosphatase activity with known substrates due to amino acid substitutions at critical sites in its PTP domain. Two paralog RPTPs, IA-2 and IA-2beta were identified as major autoantigens in type-1 diabetes mellitus. On granule exocytosis, the IA-2 cytoplasmic domain is cleaved and the resulting cytosolic fragment moves into the nucleus where it enhances the levels of phosphorylated STAT5 and STAT3, thereby inducing insulin gene transcription and granule biogenesis. IA-2 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
Spezifikation

Specifications

IA-2/PTPRN
0.19 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q16849, Q60673, Q63259
IA 2, IA 2/PTP, IA2, ICA 512, ICA3, ICA512, Islet cell antigen 512, Islet cell autoantigen 3, PTP IA 2, PTPRN, R PTP N
Rabbit
IgG
150 μL
-20°C
Primary
116660, 19275, 5798
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
PTPRN
Liquid
PTPRN
IA-2/PTPRN Fusion Protein Ag0923
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Videos
SDS
Documentos
Certificados