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STEMCELL Technologies IQ-1

Codice prodotto. 17140122
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Menge:
5 mg
Dimensione della confezione:
5 Milligramm
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Codice prodotto. Menge unitSize
17140122 5 mg 5 Milligramm
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Codice prodotto. 17140122 Fornitore STEMCELL Technologies N. del fornitore 72772

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Descrizione

WNT pathway activator; Inhibits protein phosphatase PP2A

  • IQ-1 selectively inhibits p300-dependent β-catenin signaling by binding to the PR72/130 subunit of protein phosphatase PP2A, leading to decreased phosphorylation of the β-catenin coactivator, p300, and decreased affinity of p300 for β-catenin
  • IQ-1 thereby inhibits β-catenin/p300 interaction while increasing β-catenin/CBP mediated transcription (Miyabayashi et al.)
  • Used with Wnt3a to maintain pluripotency of mouse embryonic stem (ES) cells in the absence of mouse embryonic fibroblasts (MEFs), serum, or exogenous leukemia inhibitory factor (LIF; Miyabayashi et al.)
  • Enhances expansion of mouse ES-derived cardiovascular progenitor cells (Schenke-Layland et al.)
  • Induces the conversion of cancer cells to a side population of cancer stem-like cells with high levels of drug resistance and tumorigenicity (He et al.)

Specifica

CAS 331001-62-8
Menge 5 mg
Summenformel C21H22N4O2
Reinheit ≥ 98%
Titolo del prodotto
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