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IRS1 Monoclonal Antibody (J.566.7), Invitrogen™
Mouse Monoclonal Antibody
Marke: Invitrogen MA515072
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
It is not recommended to aliquot this antibody.
IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.Spezifikation
IRS1 | |
Monoclonal | |
708 μg/mL | |
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5 | |
P35568, P35569, P35570 | |
IRS1 | |
Synthetic peptide corresponding to the sequence surrounding Ser612 of human IRS-1 | |
100 μL | |
Primary | |
Human, Mouse, Non-human Primate, Rat | |
Antibody | |
IgG1 |
Western Blot | |
J.566.7 | |
Unconjugated | |
IRS1 | |
G972R; HIRS-1; Insulin receptor substrate 1; IRS1; IRS-1; IRS1IRM; pp185 | |
Mouse | |
Affinity chromatography | |
RUO | |
16367, 25467, 3667 | |
-20°C | |
Liquid |