ITGA4 Monoclonal Antibody (5C4), Invitrogen™

Beschreibung

MA5-17102 targets ITGA4 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples. The MA5-17102 immunogen is purified recombinant fragment of human ITGA4 expressed in E. Coli. MA5-17102 detects ITGA4 which has a predicted molecular weight of approximately 115kDa.

The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.