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IWS1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Thermo Scientific PA563990
Weitere Details : Netto-Gewicht : 0.02000kg
Beschreibung
Immunogen sequence: NEELPKPRIS DSESEDPPRN QASDSENEEL PKPRVSDSES EGPQKGPASD SETEDASRHK QKPESDDDSD RENKGEDTEM QND Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 83%.
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.Spezifikation
IWS1 | |
Polyclonal | |
Unconjugated | |
IWS1 | |
1700069O15Rik; 3000008H23; AL117927; AW214353; interacts with Spt6; IWS1; IWS1 homolog; IWS1 homolog (S. cerevisiae); IWS1, SUPT6H interacting protein; Iws1l; IWS1-like protein; Protein IWS1 homolog; RGD1304762 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
55677 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q96ST2 | |
IWS1 | |
Recombinant protein corresponding to Human IWS1 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only