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LATS1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA517142
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
It is not recommended to aliquot this antibody.
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.Spezifikation
LATS1 | |
Polyclonal | |
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5 | |
O95835 | |
LATS1 | |
Synthetic peptide corresponding to amino acids surrounding Ser177 of human LATS1 | |
100 μL | |
Primary | |
Human, Non-human Primate | |
Antibody | |
IgG |
Western Blot | |
Unconjugated | |
LATS1 | |
AW208599; h-warts; large tumor suppressor; large tumor suppressor homolog 1; large tumor suppressor kinase 1; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; lats1; RGD1564085; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
9113 | |
-20°C | |
Liquid |