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ACROBiosystems Mouse Dkk-1 Protein, His Tag

Marke:  ACROBiosystems DK1-M52H6-50UG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15886567

  • 399.17 € / 50 Mikrogramm
Verfügbar ab: 11-01-2023
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Beschreibung

Beschreibung

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.0 kDa. The protein migrates as 41-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

Powder
>95% as determined by SDS-PAGE
Mouse Dkk-1, His Tag (DK1-M52H6) is expressed from human 293 cells (HEK293). It contains AA Thr 32 - His 272 (Accession # O54908).
-20°C
Dkk-1
His Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
28.0 kDa
50 µg
Thr 32 - His 272
DKK1,SK
Unconjugated
PBS, pH7.4
HEK293
Mouse
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote