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ACROBiosystems Mouse IL-4 R alpha / CD124 Protein, Fc Tag
314.52 € - 2153.18 €
Spezifikation
| Zugriffsnummer | NP_001008700 |
|---|---|
| Molekulargewicht | 51 kDa |
| Quelle | Mouse IL-4 R alpha, Fc Tag (ILR-M5252) is expressed from human 293 cells (HEK293). It contains AA Ile 26 - Arg 233 (Accession # NP_001008700). |
| Immunogen | Ile 26 - Arg 233 |
| Lagerungsbedingungen | -20°C |
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|
15897127
|
ACROBiosystems
ILR-M5252-100UG |
100 μg |
314.52 €
100 Mikrogramm |
Verfügbar ab: 23-04-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
|
15807137
|
ACROBiosystems
ILR-M5252-1MG |
1 mg |
2153.18 €
1 Milligramm |
Verfügbar ab: 23-04-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
Beschreibung
IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132).Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2- biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL-13Ra1 to form the type II receptor which is responsive to both IL-4 and IL-13. Interleukin-4 receptor has been shown to interact with SHC1.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE).Spezifikation
| NP_001008700 | |
| Mouse IL-4 R alpha, Fc Tag (ILR-M5252) is expressed from human 293 cells (HEK293). It contains AA Ile 26 - Arg 233 (Accession # NP_001008700). | |
| -20°C | |
| IL-4 R alpha | |
| Mouse | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |
| 51 kDa | |
| Ile 26 - Arg 233 | |
| IL4R,CD124,IL4RA | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |