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ACROBiosystems Mouse SIRP alpha / CD172a Protein, Mouse IgG2a Fc Tag, low endotoxin

low endotoxin

Marke:  ACROBiosystems SIA-M5252-1MG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15887697

  • 2486.22 € / 1 Milligramm
Verfügbar ab: 05-01-2023
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Beschreibung

Beschreibung

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 65.0 kDa. The protein migrates as 90-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

BAA13520.1 (G365D)
65.0 kDa
1 mg
Lys 32 - Asn 373
SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1
Unconjugated
50 mM Tris, 100 mM Glycine, pH7.5
HEK293
Mouse
Powder
>95% as determined by SDS-PAGE
Mouse SIRP alpha, Mouse IgG2a Fc Tag, low endotoxin (SIA-M5252) is expressed from human 293 cells (HEK293). It contains AA Lys 32 - Asn 373 (Accession # BAA13520.1 (G365D)).
-20°C
SIRP alpha
Mouse IgG Fc Tag
Less than 0.1 EU / µg by the LAL method.
Immune Checkpoint Proteins
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
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