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Phospho-Synapsin 1 (Ser62, Ser67) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Invitrogen PA14698
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
This antibody is predicted to react with mouse and bovine based on 100% sequence homology. In Western blot, this antibody is specific for ∽78 kDa synapsin I doublet phosphorylated at Ser 62 and 67. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.
SYN1 (synapsin 1) is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins that associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains and are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. Synapsin 1 plays a role in regulation of axonogenesis and synaptogenesis. It serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.Spezifikation
Phospho-Synapsin 1 (Ser62, Ser67) | |
Polyclonal | |
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative; pH 7.5 | |
O88935, P09951, P17600 | |
SYN1 | |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser62/67 of rat SYN1 conjugated to KLH | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Western Blot | |
Unconjugated | |
SYN1 | |
Brain protein 4.1; SYN1; Syn-1; SYN1a; SYN1b; Syn1-S; synapsin 1; synapsin I; synapsin Ia; synapsin Ib; synapsin-1; SYNI; truncated synapsin 1-S | |
Rabbit | |
Affinity chromatography | |
RUO | |
20964, 24949, 6853 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |