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Invitrogen™ PUMA alpha Recombinant Rabbit Monoclonal Antibody (23GB1935), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Marke: Invitrogen™ MA552467
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Beschreibung
PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
Spezifikation
| PUMA alpha | |
| Recombinant Monoclonal | |
| Unconjugated | |
| BBC3 | |
| BBC3; BCL2 binding component 3; Bcl-2 binding component 3; bcl-2-binding component 3; Bcl-2-binding component 3, isoforms 1/2; Bcl-2-binding component 3, isoforms 3/4; BH3-only; FLJ42994; JFY1; JFY-1; p53 up-regulated modulator of apoptosis; PUMA; PUMA/JFY1 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 170770, 27113, 317673 | |
| -20°C | |
| Liquid |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| 23GB1935 | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q80ZG6, Q99ML1, Q9BXH1 | |
| BBC3 | |
| A synthesized peptide derived from human PUMA (150-193AA). | |
| 20 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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