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DiscoverX Ready-to-Assay™ Glucagon Receptor Frozen Cells

Artikelnummer. 17355219
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Menge:
2 Fläschchen mit Zellen
Product Code. Menge
17355219 2 Fläschchen mit Zellen
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Product Code. 17355219

Brand: DiscoverX HTS112RTA

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Description

The Ready-to-Assay™ Glucagon Receptor Frozen Cells measure GCGR (GPCR) activation via an increase in intracellular calcium. Ready-to-Assay kits contain two vials of thaw-and-use cells.

The Ready-to-Assay™ Glucagon Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. glucagon) based activation of GCGR GPCR activity via detection of increasing levels of intracellular calcium. The included cells overexpress GCGR alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of GCGR , the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the cells in a convenient thaw-and-use format.

Specifications

Assay-Eingabe Glucagon
Format 2 Vials of Cells
Zur Verwendung mit (Anwendung) Frozen Cells
Primärer Agonist glucagon
Menge 2 Fläschchen mit Zellen
Zieleintrag GCGR
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