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T-bet Monoclonal Antibody (eBio4B10 (4B10)), PE-Cyanine7, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Marke: Affymetrix eBioscience 25-5825-82
Weitere Details : Netto-Gewicht : 0.25000kg
Beschreibung
Description: The eBio4B10 monoclonal antibody reacts with mouse and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN gamma, and T-Bet also regulates the expression of IFN gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN gamma, T-Bet is also known to regulate the expression of IL-12R beta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells. Applications Reported: This eBio4B10 (4B10, 4-B10) antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This eBio4B10 (4B10, 4-B10) antibody has been tested by intracellular stainign and flow cytometric analysis of normal human peripheral blood cells using the Foxp3/Transcription Factor Buffer Set (cat. 00-5523) and protocol. Please see Best Protocol section; (refer to Protocol B: One step protocol for intracellular (nuclear) proteins). This can be used at less than or equal to 0.125 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL.
T-bet Monoclonal antibody specifically detects T-bet in Human, Mouse, Rhesus Monkey samples. It is validated for Flow Cytometry.Spezifikation
| T-bet | |
| Monoclonal | |
| 0.2 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| Q9JKD8, Q9UL17 | |
| Tbx21 | |
| Affinity chromatography | |
| RUO | |
| 30009, 57765, 694044 | |
| 4° C, store in dark, DO NOT FREEZE! | |
| Liquid |
| Flow Cytometry | |
| eBio4B10 (4B10) | |
| PE-Cyanine7 | |
| Tbx21 | |
| HGNC:11599; LOW QUALITY PROTEIN: T-box transcription factor TBX21; Tbet; T-bet; TBLYM; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor 21; T-box transcription factor TBX21; TBT1; TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; transcription factor TBLYM; transcription factor T-box 21 | |
| Mouse | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rhesus Monkey | |
| Antibody | |
| IgG1 κ |
For Research Use Only.