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Invitrogen™ Human TrxR2, Recombinant Protein
Recombinant Protein
Marke: Invitrogen™ LFP0019
Weitere Details : Netto-Gewicht : 0.99000kg
Beschreibung
Thioredoxin Reductase 2 (Hu) Recombinant Protein, LF-P0019, from Invitrogen.
The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxido-reductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence(-Gly-Cys-SeCys-Gly). TrxR ishomodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55 - 58 kilodalton in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and various biological phenomena. This protein corresponds to human Thioredoxin reductase 2 (37-524 aa with N-His tag), which has a molecular weight of 55.4 kDa. Purity: >95% by SDS-PAGE.Spezifikation
Q9NNW7 | |
0.02M HEPES with 10% glycerol and no preservative; pH 7.4 | |
Human TrxR2 | |
500μg | |
-80°C, Avoid Freeze/Thaw Cycles | |
Human TrxR2 | |
Human | |
Hu | |
Recombinant | |
Recombinant |
Control | |
10587 | |
7.4 | |
E. coli | |
RUO | |
TXNRD2 | |
Unconjugated | |
E. coli | |
Lyophilized | |
purified |
in vitro research only.