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TNF alpha Rat anti-Mouse, Clone: 1F3F3D4, eBioscience™

Rat Monoclonal Antibody

Marke:  Affymetrix eBioscience 14-7325-81

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15268067

  • 80.50 € / 50 Mikrogramm

Verfügbar ab
20-05-2021

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Beschreibung

Beschreibung

Description: The 1F3F3D4 antibody reacts with mouse tumor necrosis factor-alpha (TNFaalpha), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells and CD4(+) T cells. Applications Reported: The 1F3F3D4 antibody has been reported for use in capture of mouse TNF alpha by ELISA and ELISPOT. Applications Tested: The 1F3F3D4 antibody has been tested as the capture antibody in a sandwich ELISA for analysis of mouse TNF alpha (Tumor Necrosis Factor alpha). A suitable range of concentrations of this antibody for ELISA capture is 1-4 µg/mL. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Spezifikation

Spezifikation

TNF alpha
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P06804
DADB-70P7.1, DIF, TNF-alpha, TNFA, TNFSF2
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
ELISA
1F3F3D4
Unconjugated
Tnf
Liquid
Tnf
IgM, kappa
50 μg
4° C
Primary
21926
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

For Research Use Only.