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Tolfenamic acid, 99+%

Artikelnummer. 15473869
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Artikelnummer. 15473869 Lieferant Thermo Scientific Alfa Aesar Lieferanten-Nr. J61256.09
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Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen
Regulatorischer Hinweis: Abgabe sachkundepflichtiger Stoffe und Gemische nur bei Erfüllung der Vorrausetzungen nach Chemikalienverbotsverordnung (ChemVerbotsV). Keine Abgabe an Privatpersonen.

Beschreibung

NSAID that activates calcium-activated potassium channels | CAS: 13710-19-5 | C14H12ClNO2 | 261.705 g/mol

Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 μM.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Tolfenamic acid is a non-steroidal anti-inflammatory agent. It interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNL with an IC50 value of approximately 20 µM.

Solubility
Soluble in water (slightly), acetone (∼10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (∼10 mg/ml) and ethanol (50 mg/ml).

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemische Identifikatoren

CAS 13710-19-5
Summenformel C14H12ClNO2
Molekulargewicht (g/mol) 261.705
MDL-Nummer MFCD00133865
InChI-Schlüssel YEZNLOUZAIOMLT-UHFFFAOYSA-N
Synonym tolfenamic acid, clotam, n-3-chloro-2-methylphenyl anthranilic acid, 2-3-chloro-2-methylphenyl amino benzoic acid, tolfedine, acido tolfenamico, acide tolfenamique, acidum tolfenamicum, tolfine, n-2-methyl-3-chlorophenyl anthranilic acid
PubChem CID 610479
ChEBI CHEBI:32243
IUPAC-Name 2-(3-chloro-2-methylanilino)benzoic acid
SMILES CC1=C(C=CC=C1Cl)NC2=CC=CC=C2C(=O)O

Spezifikation

Chemischer Name oder Material Tolfenamic acid
Farbe Weiß
Menge 10 g
UN-Nummer UN2811
Merck Index 14,9513
Löslichkeitsinformationen Soluble in water (slightly),acetone (∽10mg/ml),DMSO (52mg/ml at 25°C),methanol (∽10mg/ml) and ethanol (50mg/ml).
Formelmasse 261.7
Reinheit (%) ≥99%
Physikalische Form Kristallpulver

Sicherheit und Handhabung

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Produktidentifikator
  • Tolfenamic acid
 Signalwort
  • Gefahr
 Gefahrenkategorie
  • Akute Toxizität Kategorie 3
 Hazard Statement
  • H301-Giftig bei Verschlucken.
 Precautionary Statement
  • P264-Nach Gebrauch gründlich waschen.
  • P301+P310-BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt anrufen
 Supplemental information
  • MIXTURE LIST-Contain: Tolfenamic acid
SDS

RUO – Research Use Only

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