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Invitrogen™ USP5 Recombinant Rabbit Monoclonal Antibody (24GB2480)
Rabbit Recombinant Monoclonal Antibody
Marke: Invitrogen™ MA557820
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Beschreibung
USP5 Recombinant Monoclonal Antibody for Western Blot, ICC/IF, Flow
USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in unanchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Spezifikation
| USP5 | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P45974, P56399 | |
| USP5 | |
| A synthesized peptide derived from human USP5 (aa 770-835). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| 24GB2480 | |
| Unconjugated | |
| USP5 | |
| AA407472; deubiquitinating enzyme 5; EGK_03293; Isopeptidase T; Isot; ISOT-1; testicular tissue protein Li 218; ubiquitin carboxy terminal hydrolase T; ubiquitin carboxyl-terminal hydrolase 5; ubiquitin isopeptidase T; ubiquitin specific peptidase 5; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5; ubiquitin specific protease 5 (isopeptidase T); ubiquitin thioesterase 5; ubiquitin thiolesterase 5; ubiquitin-specific protease-5 (ubiquitin isopeptidase T); ubiquitin-specific-processing protease 5; Ucht; Usp5 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 22225, 297593, 8078 | |
| -20°C | |
| Liquid |
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