YARS Polyclonal Antibody, Invitrogen™

Beschreibung

Immunogen sequence: GNVENNGVLS FIKHVLFPLK SEFVILRDEK WGGNKTYTAY VDLEKDFAAE VVHPGDLKNS VEVALNKLLD PIREKFNTPA LKKLASAAYP DPSKQKPMAK GPAKNSEPEE VIPSRLDIRV GKIITVEKHP DAD Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 93%.

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.